Does levocetirizine contain wheat or gluten as an excipient?

We cross-check each levocetirizine product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. Of 12 product labels we cross-checked, 1 list a gluten-derived ingredient outright. Generics from different manufacturers can differ — check which manufacturer's version your pharmacy dispensed before assuming any fill is safe.

Can different manufacturers' generic versions of levocetirizine have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of levocetirizine from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

Last verified May 17, 2026 · 12 product labels screened

Is levocetirizine gluten-free?

Some formulations contain gluten. Of 12 product labels we cross-checked, 1 list a gluten-derived ingredient outright. Generics from different manufacturers can differ — check which manufacturer's version your pharmacy dispensed before assuming any fill is safe.

Drug context

About levocetirizine

Levocetirizine is a second-generation antihistamine for allergic rhinitis and hives, sold under brand names including Xyzal.

Why this matters

Different manufacturers, different ingredients

Generics of levocetirizine use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 12 we checked

01

Padagis / Perrigo contains gluten

Mangione 2024 · levocetirizine dihydrochloride 2.5 mg/5 mL oral solution [Padagis / Perrigo] · label dated 2025-06-09

Gluten on the label: Manufacturer-declared gluten content (Matson et al. 2025 (peer-reviewed): the manufacturer of this NDC confirmed that the product contains gluten.)
View source label →
02

(manufacturer not listed) worth a call to confirm

Mangione 2024 · levocetirizine dihydrochloride 2.5 mg/5 mL oral solution (no confirmed-GF version found) · label dated 2025-06-09

Worth a call to the maker: No confirmed gluten-free formulation available
View source label →
03

Chattem, Inc. nothing flagged on the label

US label (DailyMed) · XYZAL ALLERGY 24HR (LEVOCETIRIZINE DIHYDROCHLORIDE) TABLET [CHATTEM, INC.] · label dated Mar 10, 2026

Inactive ingredients HYPROMELLOSES · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
04

Little Pharma, Inc. nothing flagged on the label

US label (DailyMed) · CURIST ALLERGY RELIEF (LEVOCETIRIZINE DIHYDROCHLORIDE 5 MG) TABLET [LITTLE PHARMA, INC.] · label dated Mar 09, 2026

Inactive ingredients HYPROMELLOSE 2910 (3 MPA.S) · HYPROMELLOSE 2910 (6 MPA.S) · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
05

Northwind Health Company, LLC nothing flagged on the label

US label (DailyMed) · LEVOCETIRIZINE DIHYDROCHLORIDE TABLET [NORTHWIND HEALTH COMPANY, LLC] · label dated Feb 26, 2026

Inactive ingredients HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
06

Sportpharm LLC nothing flagged on the label

US label (DailyMed) · LEVOCETIRIZINE DIHYDROCHLORIDE TABLET, FILM COATED [SPORTPHARM LLC] · label dated Feb 18, 2026

Inactive ingredients HYPROMELLOSE 2910 (3 MPA.S) · HYPROMELLOSE 2910 (6 MPA.S) · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
07

Northwind Health Company, LLC nothing flagged on the label

US label (DailyMed) · LEVOCETIRIZINE DIHYDROCHLORIDE TABLET [NORTHWIND HEALTH COMPANY, LLC] · label dated Feb 04, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · HYPROMELLOSES · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYSORBATE 80 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
08

Chattem, Inc. nothing flagged on the label

US label (DailyMed) · CHILDRENS XYZAL ALLERGY (LEVOCETIRIZINE DIHYDROCHLORIDE) SOLUTION [CHATTEM, INC.] · label dated Feb 02, 2026

Inactive ingredients ACETIC ACID · GLYCERIN · MALTITOL · METHYLPARABEN · PROPYLPARABEN · SACCHARIN SODIUM · SODIUM ACETATE · WATER
View source label →
09

Glenmark Pharmaceuticals Inc., USA nothing flagged on the label

US label (DailyMed) · LEVOCETIRIZINE DIHYDROCHLORIDE TABLET [GLENMARK PHARMACEUTICALS INC., USA] · label dated Jan 23, 2026

Inactive ingredients HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
10

Walgreens Company nothing flagged on the label

US label (DailyMed) · LEVOCETIRIZINE DIHYDROCHLORIDE TABLET, COATED [WALGREENS COMPANY] · label dated Jan 21, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · HYPROMELLOSES · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · Polyethylene Glycol, Unspecified · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
11

Target Corporation nothing flagged on the label

US label (DailyMed) · LEVOCETIRIZINE DIHYDROCHLORIDE TABLET, COATED [TARGET CORPORATION] · label dated Jan 21, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · HYPROMELLOSES · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL, UNSPECIFIED · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
12

Walmart Inc. nothing flagged on the label

US label (DailyMed) · LEVOCETIRIZINE DIHYDROCHLORIDE TABLET, COATED [WALMART INC.] · label dated Jan 21, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · HYPROMELLOSES · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL, UNSPECIFIED · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

Keep checking

Other drugs people look up

Important. This page is informational. Drug labels can change without notice; a manufacturer attestation is point-in-time, not a warranty. If you have celiac disease and your pharmacy switches manufacturers, re-screen the new label before taking the dispensed product. For a definitive answer, call the manufacturer's medical-information line with the NDC code from your prescription bottle.