Does metoprolol contain wheat or gluten as an excipient?

We cross-check each metoprolol product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. At least one manufacturer has formally attested their formulation contains no gluten. Of 12 labels we checked, 2 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Can different manufacturers' generic versions of metoprolol have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of metoprolol from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

Last verified May 17, 2026 · 12 product labels screened

Is metoprolol gluten-free?

Confirmed gluten-free by at least one manufacturer. At least one manufacturer has formally attested their formulation contains no gluten. Of 12 labels we checked, 2 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Drug context

About metoprolol

Metoprolol is a beta blocker used for high blood pressure, chest pain, and after a heart attack, sold under brand names including Lopressor, Toprol-XL.

Why this matters

Different manufacturers, different ingredients

Generics of metoprolol use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 12 we checked

01

(manufacturer not listed) manufacturer-attested gluten-free

Plogsted list · Metoprolol · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
02

Apothecon manufacturer-attested gluten-free

Plogsted list · Metoprolol (Apothecon, Novapharm) · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
03

Aphena Pharma Solutions - Tennessee, LLC nothing flagged on the label

US label (DailyMed) · METOPROLOL SUCCINATE TABLET, FILM COATED, EXTENDED RELEASE [APHENA PHARMA SOLUTIONS - T… · label dated May 15, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CELLULOSE, MICROCRYSTALLINE · CROSCARMELLOSE SODIUM · ETHYLCELLULOSE (10 MPA.S) · HYDROGENATED COTTONSEED OIL · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSES · METHYLENE CHLORIDE · POLYETHYLENE GLYCOL 6000 · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE
View source label →
04

Coupler LLC nothing flagged on the label

US label (DailyMed) · METOPROLOL TARTRATE (METOPROLOL) TABLET [COUPLER LLC] · label dated May 11, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · FD&C BLUE NO. 1 · FD&C BLUE NO. 2 · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POVIDONE K30 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
05

Zydus Lifesciences Limited nothing flagged on the label

US label (DailyMed) · METOPROLOL SUCCINATE TABLET, EXTENDED RELEASE [ZYDUS LIFESCIENCES LIMITED] · label dated May 06, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · CROSCARMELLOSE SODIUM · ETHYLCELLULOSE (10 MPA.S) · GLYCERIN · HYPROMELLOSES · MAGNESIUM STEARATE · METHYLCELLULOSE (15 CPS) · POLYETHYLENE GLYCOL, UNSPECIFIED · POVIDONE K30 · SILICON DIOXIDE · TALC · TITANIUM DIOXIDE
View source label →
06

ST. MARY'S MEDICAL PARK PHARMACY nothing flagged on the label

US label (DailyMed) · METOPROLOL TARTRATE TABLET [ST. MARY'S MEDICAL PARK PHARMACY ] · label dated May 06, 2026

Inactive ingredients LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO
View source label →
07

Zydus Pharmaceuticals (USA) Inc. nothing flagged on the label

US label (DailyMed) · METOPROLOL SUCCINATE TABLET, EXTENDED RELEASE [ZYDUS PHARMACEUTICALS (USA) INC.] · label dated May 06, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · CROSCARMELLOSE SODIUM · ETHYLCELLULOSE (10 MPA.S) · GLYCERIN · HYPROMELLOSES · MAGNESIUM STEARATE · METHYLCELLULOSE (15 CPS) · POLYETHYLENE GLYCOL, UNSPECIFIED · POVIDONE K30 · SILICON DIOXIDE · TALC · TITANIUM DIOXIDE
View source label →
08

Hospira, Inc. nothing flagged on the label

US label (DailyMed) · METOPROLOL TARTRATE INJECTION, SOLUTION [HOSPIRA, INC.] · label dated May 06, 2026

Inactive ingredients SODIUM CHLORIDE · WATER
View source label →
09

ST. MARY'S MEDICAL PARK PHARMACY nothing flagged on the label

US label (DailyMed) · METOPROLOL TARTRATE TABLET [ST. MARY'S MEDICAL PARK PHARMACY] · label dated Apr 30, 2026

Inactive ingredients LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO
View source label →
10

Redpharm Drug nothing flagged on the label

US label (DailyMed) · METOPROLOL SUCCINATE TABLET, FILM COATED, EXTENDED RELEASE [REDPHARM DRUG] · label dated Apr 22, 2026

Inactive ingredients ACETYLTRIBUTYL CITRATE · CARNAUBA WAX · ETHYLCELLULOSE (10 MPA.S) · GLYCERYL DIBEHENATE · HYDROXYPROPYL CELLULOSE (110000 WAMW) · HYPROMELLOSE 2910 (6 MPA.S) · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 6000 · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · TITANIUM DIOXIDE
View source label →
11

Coupler LLC nothing flagged on the label

US label (DailyMed) · METOPROLOL SUCCINATE TABLET, EXTENDED RELEASE [COUPLER LLC] · label dated Apr 22, 2026

Inactive ingredients CROSPOVIDONE · ETHYLCELLULOSE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 3350 · POLYETHYLENE GLYCOL 6000 · POLYVINYL ALCOHOL · SILICON DIOXIDE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
12

QPharma, Inc. nothing flagged on the label

US label (DailyMed) · METOPROLOL TARTRATE TABLET [QPHARMA, INC.] · label dated Apr 20, 2026

Inactive ingredients LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO
View source label →

Try it live

Or screen metoprolol right now

DailyMed updates daily and we have ~76 drugs in our static landing pages — for everything else, the live search is faster.

Screen metoprolol live →

Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

Keep checking

Other drugs people look up

Important. This page is informational. Drug labels can change without notice; a manufacturer attestation is point-in-time, not a warranty. If you have celiac disease and your pharmacy switches manufacturers, re-screen the new label before taking the dispensed product. For a definitive answer, call the manufacturer's medical-information line with the NDC code from your prescription bottle.