Does naproxen contain wheat or gluten as an excipient?

We cross-check each naproxen product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. At least one manufacturer has formally attested their formulation contains no gluten. Of 11 labels we checked, 1 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Can different manufacturers' generic versions of naproxen have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of naproxen from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

Last verified May 17, 2026 · 11 product labels screened

Is naproxen gluten-free?

Confirmed gluten-free by at least one manufacturer. At least one manufacturer has formally attested their formulation contains no gluten. Of 11 labels we checked, 1 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Drug context

About naproxen

Naproxen is a longer-acting NSAID for pain and inflammation, sold under brand names including Aleve, Naprosyn.

Why this matters

Different manufacturers, different ingredients

Generics of naproxen use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 11 we checked

01

Novapharm manufacturer-attested gluten-free

Plogsted list · Naproxen (Novapharm) · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
02

CVS Pharmacy nothing flagged on the label

US label (DailyMed) · NAPROXEN SODIUM CAPSULE, LIQUID FILLED [CVS PHARMACY] · label dated May 14, 2026

Inactive ingredients ALCOHOL · FD&C BLUE NO. 1 · GELATIN · GLYCERIN · LACTIC ACID · LECITHIN, SOYBEAN · LIGHT MINERAL OIL · POLYETHYLENE GLYCOL, UNSPECIFIED · POVIDONE, UNSPECIFIED · PROPYLENE GLYCOL · SHELLAC · SORBITAN · SORBITOL · TITANIUM DIOXIDE · WATER
View source label →
03

Bionpharma Inc. nothing flagged on the label

US label (DailyMed) · NAPROXEN SODIUM CAPSULE, LIQUID FILLED [BIONPHARMA INC.] · label dated May 13, 2026

Inactive ingredients FD&C BLUE NO. 1 · GELATIN · GLYCERIN · LACTIC ACID · MANNITOL · POLYETHYLENE GLYCOL, UNSPECIFIED · POVIDONE · PROPYLENE GLYCOL · SORBITAN · SORBITOL · WATER
View source label →
04

Publix Super Markets Inc nothing flagged on the label

US label (DailyMed) · ALL DAY RELIEF (NAPROXEN SODIUM) TABLET, FILM COATED [PUBLIX SUPER MARKETS INC] · label dated May 11, 2026

Inactive ingredients FD&C BLUE NO. 2 ALUMINUM LAKE · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POVIDONE, UNSPECIFIED · TALC · TITANIUM DIOXIDE
View source label →
05

United Natural Foods, Inc. dba UNFI nothing flagged on the label

US label (DailyMed) · EQUALINE NAPROXEN SODIUM (NAPROXEN SODIUM) TABLET, FILM COATED [UNITED NATURAL FOODS, I… · label dated May 11, 2026

Inactive ingredients FD&C BLUE NO. 2 ALUMINUM LAKE · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POVIDONE, UNSPECIFIED · TALC · TITANIUM DIOXIDE
View source label →
06

Rugby Laboratories nothing flagged on the label

US label (DailyMed) · RUGBY ALL DAY RELIEF (NAPROXEN SODIUM) TABLET, FILM COATED [RUGBY LABORATORIES] · label dated May 11, 2026

Inactive ingredients FD&C BLUE NO. 2 ALUMINUM LAKE · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POVIDONE, UNSPECIFIED · TALC · TITANIUM DIOXIDE
View source label →
07

Walgreen Company nothing flagged on the label

US label (DailyMed) · ALL NIGHT PAIN RELIEF PM (DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM) TABLET, FILM … · label dated Apr 30, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · FD&C BLUE NO. 1 ALUMINUM LAKE · FD&C BLUE NO. 2 ALUMINUM LAKE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYVINYL ALCOHOL, UNSPECIFIED · POVIDONE, UNSPECIFIED · SILICON DIOXIDE · TALC · TITANIUM DIOXIDE
View source label →
08

Amazon.com Services LLC nothing flagged on the label

US label (DailyMed) · NAPROXEN SODIUM CAPSULE, LIQUID FILLED [AMAZON.COM SERVICES LLC] · label dated Apr 28, 2026

Inactive ingredients FD&C BLUE NO. 1 · GELATIN · GLYCERIN · LACTIC ACID · MANNITOL · POLYETHYLENE GLYCOL, UNSPECIFIED · POVIDONE K30 · PROPYLENE GLYCOL · SORBITAN · SORBITOL · WATER
View source label →
09

Sportpharm LLC nothing flagged on the label

US label (DailyMed) · NAPROXEN TABLET [SPORTPHARM LLC] · label dated Apr 27, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · FERRIC OXIDE YELLOW · MAGNESIUM STEARATE · POVIDONE, UNSPECIFIED
View source label →
10

Sportpharm LLC nothing flagged on the label

US label (DailyMed) · MEDIQUE MEDIPROXEN (NAPROXEN SODIUM) TABLET, FILM COATED [SPORTPHARM LLC] · label dated Apr 27, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · FD&C BLUE NO. 2 · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYVINYL ALCOHOL · POVIDONE · STARCH, CORN · TALC · TITANIUM DIOXIDE
View source label →
11

Bionpharma Inc. nothing flagged on the label

US label (DailyMed) · NAPROXEN SODIUM CAPSULE, LIQUID FILLED [BIONPHARMA INC.] · label dated Apr 22, 2026

Inactive ingredients FD&C BLUE NO. 1 · GELATIN · GLYCERIN · LACTIC ACID · MANNITOL · POLYETHYLENE GLYCOL, UNSPECIFIED · POVIDONE · PROPYLENE GLYCOL · SORBITAN · SORBITOL · WATER
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

Keep checking

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Important. This page is informational. Drug labels can change without notice; a manufacturer attestation is point-in-time, not a warranty. If you have celiac disease and your pharmacy switches manufacturers, re-screen the new label before taking the dispensed product. For a definitive answer, call the manufacturer's medical-information line with the NDC code from your prescription bottle.