Does omeprazole contain wheat or gluten as an excipient?

We cross-check each omeprazole product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. Mostly yes — but worth a quick call to the manufacturer for some generics. Of 10 product labels we checked, 9 are clean, 0 are confirmed gluten-free by the maker, and 1 contain an inactive ingredient (typically a source-ambiguous starch) whose botanical origin isn't fully disclosed. None contained confirmed gluten.

Can different manufacturers' generic versions of omeprazole have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of omeprazole from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

Last verified May 17, 2026 · 10 product labels screened

Is omeprazole gluten-free?

Looks mostly clean — worth verifying with the maker. Mostly yes — but worth a quick call to the manufacturer for some generics. Of 10 product labels we checked, 9 are clean, 0 are confirmed gluten-free by the maker, and 1 contain an inactive ingredient (typically a source-ambiguous starch) whose botanical origin isn't fully disclosed. None contained confirmed gluten.

Drug context

About omeprazole

Omeprazole is a proton-pump inhibitor used for acid reflux and ulcers, sold under brand names including Prilosec.

Why this matters

Different manufacturers, different ingredients

Generics of omeprazole use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 10 we checked

01

American Sales Company worth a call to confirm

US label (DailyMed) · CARE ONE OMEPRAZOLE (OMEPRAZOLE) TABLET, DELAYED RELEASE [AMERICAN SALES COMPANY] · label dated Apr 20, 2026

Worth a call to the maker: SODIUM STARCH GLYCOLATE TYPE A

Inactive ingredients CARNAUBA WAX · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · HYPROMELLOSE ACETATE SUCCINATE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MONOETHANOLAMINE · PROPYLENE GLYCOL · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A · SODIUM STEARATE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
02

Safeway nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE CAPSULE, DELAYED RELEASE [SAFEWAY] · label dated May 04, 2026

Inactive ingredients FD&C YELLOW NO. 6 · FERRIC OXIDE RED · GELATIN, UNSPECIFIED · GLYCERYL MONOSTEARATE · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MEGLUMINE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYSORBATE 80 · SHELLAC · SODIUM LAURYL SULFATE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
03

ST. MARY'S MEDICAL PARK PHARMACY nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE CAPSULE, DELAYED RELEASE [ST. MARY'S MEDICAL PARK PHARMACY] · label dated Apr 30, 2026

Inactive ingredients D&C RED NO. 28 · FD&C BLUE NO. 1 · FD&C RED NO. 40 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN · GLYCERYL MONOSTEARATE · HYPROMELLOSES · MEGLUMINE · METHACRYLIC ACID - ETHYL ACRYLATE COPOLYMER (1:1) TYPE A · POLOXAMER 407 · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · RAW SUGAR · SHELLAC · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
04

Golden State Medical Supply, Inc. nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE CAPSULE, DELAYED RELEASE PELLETS [GOLDEN STATE MEDICAL SUPPLY, INC.] · label dated Apr 29, 2026

Inactive ingredients ALCOHOL · AMMONIA · BUTYL ALCOHOL · DIBUTYL SEBACATE · ETHYLCELLULOSE (20 MPA.S) · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · ISOPROPYL ALCOHOL · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · OLEIC ACID · POLYSORBATE 80 · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · SODIUM LAURYL SULFATE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
05

Preferred Phharmaceuticals Inc. nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE CAPSULE, DELAYED RELEASE [PREFERRED PHHARMACEUTICALS INC.] · label dated Apr 22, 2026

Inactive ingredients AMMONIA · FERRIC OXIDE RED · FERROSOFERRIC OXIDE · GELATIN, UNSPECIFIED · GLYCERYL MONOSTEARATE · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSE 2910 (5 MPA.S) · LACTOSE MONOHYDRATE · MANNITOL · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYSORBATE 80 · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SODIUM LAURYL SULFATE · SODIUM PHOSPHATE, DIBASIC, DIHYDRATE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
06

AMERISOURCEBERGEN DRUG CORPORATION nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE TABLET, DELAYED RELEASE [AMERISOURCEBERGEN DRUG CORPORATION] · label dated Apr 20, 2026

Inactive ingredients AMMONIA · BUTYL ALCOHOL · CARNAUBA WAX · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · HYPROMELLOSE ACETATE SUCCINATE 06081224 (3 MM2/S) · HYPROMELLOSES · LACTOSE MONOHYDRATE · MONOETHANOLAMINE · POLYVINYL ALCOHOL · POVIDONE · PROPYLENE GLYCOL · Polyethylene Glycol 3350 · SHELLAC · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A POTATO · SODIUM STEARATE · SODIUM STEARYL FUMARATE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
07

Bimeda, Inc. nothing flagged on the label

US label (DailyMed) · GASTROBIM (OMEPRAZOLE) PASTE [BIMEDA, INC.] · label dated Apr 17, 2026
View source label →
08

ST. MARY'S MEDICAL PARK PHARMACY nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE CAPSULE, DELAYED RELEASE [ST. MARY'S MEDICAL PARK PHARMACY ] · label dated Apr 15, 2026

Inactive ingredients ANHYDROUS LACTOSE · CETYL ALCOHOL · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C RED NO. 40 · FD&C YELLOW NO. 6 · GELATIN, UNSPECIFIED · HYPROMELLOSE PHTHALATE (31% PHTHALATE, 40 CST) · HYPROMELLOSE, UNSPECIFIED · MANNITOL · SODIUM LAURYL SULFATE · SODIUM PHOSPHATE, DIBASIC, DIHYDRATE · TITANIUM DIOXIDE
View source label →
09

Grocery Outlet, Inc. nothing flagged on the label

US label (DailyMed) · 24 HOUR OMEPRAZOLE (OMEPRAZOLE 20 MG) TABLET, DELAYED RELEASE [GROCERY OUTLET, INC.] · label dated Apr 03, 2026

Inactive ingredients CROSPOVIDONE, UNSPECIFIED · DIMETHICONE, UNSPECIFIED · FERRIC OXIDE RED · GLYCERYL MONOSTEARATE · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYETHYLENE GLYCOL 6000 · POLYSORBATE 80 · SILICON DIOXIDE · SODIUM STEARYL FUMARATE · STARCH, CORN · SUCROSE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →
10

CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED nothing flagged on the label

US label (DailyMed) · OMEPRAZOLE CAPSULE, DELAYED RELEASE [CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED] · label dated Apr 02, 2026

Inactive ingredients FD&C YELLOW NO. 6 · FERRIC OXIDE RED · GELATIN, UNSPECIFIED · GLYCERYL MONOSTEARATE · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MEGLUMINE · METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYSORBATE 80 · SHELLAC · SODIUM LAURYL SULFATE · TALC · TITANIUM DIOXIDE · TRIETHYL CITRATE
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

Keep checking

Other drugs people look up

Important. This page is informational. Drug labels can change without notice; a manufacturer attestation is point-in-time, not a warranty. If you have celiac disease and your pharmacy switches manufacturers, re-screen the new label before taking the dispensed product. For a definitive answer, call the manufacturer's medical-information line with the NDC code from your prescription bottle.