Is sertraline gluten-free?
Looks mostly clean — worth verifying with the maker. Mostly yes — but worth a quick call to the manufacturer for some generics. Of 10 product labels we checked, 8 are clean, 0 are confirmed gluten-free by the maker, and 2 contain an inactive ingredient (typically a source-ambiguous starch) whose botanical origin isn't fully disclosed. None contained confirmed gluten.
Drug context
About sertraline
Sertraline is an SSRI antidepressant used for depression, anxiety, OCD, and PTSD, sold under brand names including Zoloft.
Why this matters
Different manufacturers, different ingredients
Generics of sertraline use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.
The labels
The 10 we checked
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01Granules Pharmaceuticals Inc. worth a call to confirm
Worth a call to the maker: SODIUM STARCH GLYCOLATE TYPE A
Inactive ingredients CALCIUM PHOSPHATE, DIBASIC, ANHYDROUS · CELLULOSE, MICROCRYSTALLINE · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C BLUE NO. 2 · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · HYDROXYPROPYL CELLULOSE, LOW SUBSTITUTED · HYPROMELLOSE 2910 (5 MPA.S) · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A · TALC · TITANIUM DIOXIDE
View source label → -
02Northwind Health Company, LLC worth a call to confirm
Worth a call to the maker: SODIUM STARCH GLYCOLATE TYPE A
Inactive ingredients CALCIUM PHOSPHATE, DIBASIC, ANHYDROUS · CELLULOSE, MICROCRYSTALLINE · FD&C BLUE NO. 1 · FD&C BLUE NO. 2 · HYDROXYPROPYL CELLULOSE, LOW SUBSTITUTED · HYPROMELLOSE 2910 (5 MPA.S) · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A · TALC · TITANIUM DIOXIDE
View source label → -
03Coupler LLC nothing flagged on the label
Inactive ingredients DIBASIC CALCIUM PHOSPHATE DIHYDRATE · FD&C BLUE NO. 2 · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSE 2910 (6 MPA.S) · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SODIUM STARCH GLYCOLATE TYPE A POTATO · TITANIUM DIOXIDE
View source label → -
04St. Mary's Medical Park Pharmacy nothing flagged on the label
Inactive ingredients DIBASIC CALCIUM PHOSPHATE DIHYDRATE · FD&C BLUE NO. 2 · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSE 2910 (6 MPA.S) · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SODIUM STARCH GLYCOLATE TYPE A POTATO · TITANIUM DIOXIDE
View source label → -
05Coupler LLC nothing flagged on the label
Inactive ingredients DIBASIC CALCIUM PHOSPHATE DIHYDRATE · FERRIC OXIDE YELLOW · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSE 2910 (6 MPA.S) · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SODIUM STARCH GLYCOLATE TYPE A POTATO · TITANIUM DIOXIDE
View source label → -
06Coupler LLC nothing flagged on the label
Inactive ingredients ANHYDROUS DIBASIC CALCIUM PHOSPHATE · ASCORBIC ACID · CELLULOSE, MICROCRYSTALLINE · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C RED NO. 40 · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSES · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYSORBATE 80 · SODIUM STARCH GLYCOLATE TYPE A POTATO · TITANIUM DIOXIDE · VANILLIN
View source label → -
07Legacy Pharmaceutical Packaging, LLC nothing flagged on the label
Inactive ingredients CELLULOSE, MICROCRYSTALLINE · D&C YELLOW NO. 10 · DIBASIC CALCIUM PHOSPHATE DIHYDRATE · FD&C BLUE NO. 2 · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSE 2910 (3 MPA.S) · HYPROMELLOSE 2910 (6 MPA.S) · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SODIUM STARCH GLYCOLATE TYPE A POTATO · TITANIUM DIOXIDE
View source label → -
08Amneal Pharmaceuticals NY LLC nothing flagged on the label
Inactive ingredients AMMONIA · ANHYDROUS LACTOSE · FD&C BLUE NO. 1 · FD&C YELLOW NO. 5 · FERROSOFERRIC OXIDE · GELATIN · MAGNESIUM STEARATE · POTASSIUM HYDROXIDE · PROPYL GALLATE · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label → -
09Lupin Pharmaceuticals, Inc. nothing flagged on the label
Inactive ingredients ANHYDROUS DIBASIC CALCIUM PHOSPHATE · ASCORBIC ACID · CELLULOSE, MICROCRYSTALLINE · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C BLUE NO. 2 · FD&C RED NO. 40 · FERRIC OXIDE YELLOW · HYDROXYPROPYL CELLULOSE (1600000 WAMW) · HYPROMELLOSES · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYSORBATE 80 · SODIUM STARCH GLYCOLATE TYPE A POTATO · TITANIUM DIOXIDE · VANILLIN
View source label → -
10Zydus Pharmaceuticals (USA) Inc. nothing flagged on the label
Inactive ingredients CELLULOSE, MICROCRYSTALLINE · CROSCARMELLOSE SODIUM · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C RED NO. 40 · FERROSOFERRIC OXIDE · GELATIN · HYDROXYPROPYL CELLULOSE (45000 WAMW) · MAGNESIUM STEARATE · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
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Or screen sertraline right now
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Background
What “gluten in a medication” actually means
Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.
The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →
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