Is cyclobenzaprine gluten-free?
Confirmed gluten-free by at least one manufacturer. At least one manufacturer has formally attested their formulation contains no gluten. Of 11 labels we checked, 1 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.
Drug context
About cyclobenzaprine
Cyclobenzaprine is a skeletal muscle relaxant used for short-term relief of muscle spasm, sold under brand names including Flexeril.
Why this matters
Different manufacturers, different ingredients
Generics of cyclobenzaprine use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.
The labels
The 11 we checked
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01Mylan manufacturer-attested gluten-free
Listed gluten-free in Plogsted Alpha List (2017-04-28)
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02Coupler LLC nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C BLUE NO. 2 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
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03QPharma, Inc. nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C BLUE NO. 2 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
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04Sportpharm LLC nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
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05ASCLEMED USA INC. nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
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06Direct_Rx nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
View source label → -
07DirectRx nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · HYDROXYPROPYL CELLULOSE, UNSPECIFIED · HYPROMELLOSE 2910 (15 MPA.S) · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE 102 · SILICON DIOXIDE · TALC · TITANIUM DIOXIDE · TRIACETIN
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08Northwind Health Company, LLC nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C BLUE NO. 2 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
View source label → -
09Asclemed USA, Inc. nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CELLULOSE, MICROCRYSTALLINE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICON DIOXIDE · STARCH, CORN · TITANIUM DIOXIDE
View source label → -
10NuCare Pharmaceuticals, Inc. nothing flagged on the label
Inactive ingredients ANHYDROUS LACTOSE · CROSPOVIDONE (15 MPA.S AT 5%) · D&C YELLOW NO. 10 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · POLYSORBATE 80 · SILICIFIED MICROCRYSTALLINE CELLULOSE (50 .MICRO.M) · STARCH, CORN · TITANIUM DIOXIDE
View source label → -
11Cardinal Health 107, LLC nothing flagged on the label
Inactive ingredients CROSCARMELLOSE SODIUM · FERRIC OXIDE YELLOW · HYPROMELLOSE 2910 (6 MPA.S) · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · POLYETHYLENE GLYCOL 400 · STARCH, CORN · TITANIUM DIOXIDE
View source label →
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Background
What “gluten in a medication” actually means
Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.
The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →
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