Does doxycycline contain wheat or gluten as an excipient?

We cross-check each doxycycline product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. At least one manufacturer has formally attested their formulation contains no gluten. Of 11 labels we checked, 1 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Can different manufacturers' generic versions of doxycycline have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of doxycycline from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

Last verified May 17, 2026 · 11 product labels screened

Is doxycycline gluten-free?

Confirmed gluten-free by at least one manufacturer. At least one manufacturer has formally attested their formulation contains no gluten. Of 11 labels we checked, 1 are confirmed by the maker and 10 show nothing flagged. Confirm the brand or generic on your bottle matches one of the attesting manufacturers below.

Drug context

About doxycycline

Doxycycline is a tetracycline-class antibiotic used for acne, Lyme disease, and respiratory infections, sold under brand names including Vibramycin, Oracea.

Why this matters

Different manufacturers, different ingredients

Generics of doxycycline use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 11 we checked

01

Mylan manufacturer-attested gluten-free

Plogsted list · Doxycycline (Mylan, Watson, West-Ward) · label dated 2017-04-28

Listed gluten-free in Plogsted Alpha List (2017-04-28)
View source label →
02

Steriscience Specialties Private Limited nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [STERISCIENCE SPECIALTIES PRIV… · label dated May 11, 2026

Inactive ingredients ASCORBIC ACID · MANNITOL · NITROGEN · WATER
View source label →
03

ST. MARY'S MEDICAL PARK PHARMACY nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE CAPSULE [ST. MARY'S MEDICAL PARK PHARMACY] · label dated May 04, 2026

Inactive ingredients FD&C BLUE NO. 1 · FERRIC OXIDE RED · GELATIN · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POTASSIUM HYDROXIDE · SHELLAC · SODIUM LAURYL SULFATE · TITANIUM DIOXIDE
View source label →
04

Alembic Pharmaceuticals Inc. nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE HYCLATE TABLET, DELAYED RELEASE [ALEMBIC PHARMACEUTICALS INC.] · label dated Apr 30, 2026

Inactive ingredients ANHYDROUS LACTOSE · CROSCARMELLOSE SODIUM · CROSPOVIDONE · HYDROXYPROPYL CELLULOSE, LOW SUBSTITUTED · HYPROMELLOSE PHTHALATE (24% PHTHALATE, 55 CST) · HYPROMELLOSE, UNSPECIFIED · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 6000 · POVIDONE K30 · SILICON DIOXIDE · SODIUM CHLORIDE · STARCH, CORN · TALC · TRIETHYL CITRATE
View source label →
05

Par Health USA, LLC nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [PAR HEALTH USA, LLC] · label dated Apr 22, 2026

Inactive ingredients ASCORBIC ACID
View source label →
06

Meitheal Pharmaceuticals Inc. nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [MEITHEAL PHARMACEUTICALS INC.] · label dated Apr 10, 2026

Inactive ingredients ASCORBIC ACID · MANNITOL
View source label →
07

Direct_Rx nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE HYCLATE TABLET [DIRECT_RX] · label dated Mar 09, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · HYPROMELLOSE 2910 (6 MPA.S) · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL 400 · SILICON DIOXIDE · TITANIUM DIOXIDE · WATER
View source label →
08

Northwind Health Company, LLC nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE CAPSULE [NORTHWIND HEALTH COMPANY, LLC] · label dated Feb 18, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · FERRIC OXIDE RED · FERRIC OXIDE YELLOW · FERROSOFERRIC OXIDE · GELATIN · MAGNESIUM STEARATE · POTASSIUM HYDROXIDE · PROPYLENE GLYCOL · SHELLAC · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A CORN · TITANIUM DIOXIDE
View source label →
09

Mayne Pharma Commercial LLC nothing flagged on the label

US label (DailyMed) · DORYX MPC (DOXYCYCLINE HYCLATE) TABLET, DELAYED RELEASE DORYX MPC (DOXYCYCLINE HYCLATE)… · label dated Feb 18, 2026

Inactive ingredients ANHYDROUS LACTOSE · CROSPOVIDONE (120 .MU.M) · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SODIUM CHLORIDE · SODIUM LAURYL SULFATE · STARCH, CORN · TALC
View source label →
10

REMEDYREPACK INC. nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE HYCLATE CAPSULE [REMEDYREPACK INC.] · label dated May 15, 2026

Inactive ingredients ALCOHOL · BUTYL ALCOHOL · D&C YELLOW NO. 10 · FD&C BLUE NO. 1 · FD&C BLUE NO. 2 · FD&C RED NO. 40 · FERROSOFERRIC OXIDE · LACTOSE MONOHYDRATE · MAGNESIUM STEARATE · PROPYLENE GLYCOL · TITANIUM DIOXIDE
View source label →
11

Cardinal Health 107, LLC nothing flagged on the label

US label (DailyMed) · DOXYCYCLINE HYCLATE TABLET, COATED [CARDINAL HEALTH 107, LLC] · label dated May 04, 2026

Inactive ingredients CROSCARMELLOSE SODIUM · DOCUSATE SODIUM · FD&C BLUE NO. 2 · FD&C YELLOW NO. 6 · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · SILICON DIOXIDE · SODIUM BENZOATE · STARCH, CORN · TITANIUM DIOXIDE
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

Keep checking

Other drugs people look up

Important. This page is informational. Drug labels can change without notice; a manufacturer attestation is point-in-time, not a warranty. If you have celiac disease and your pharmacy switches manufacturers, re-screen the new label before taking the dispensed product. For a definitive answer, call the manufacturer's medical-information line with the NDC code from your prescription bottle.