Does trazodone contain wheat or gluten as an excipient?

We cross-check each trazodone product label against four data sources: DailyMed (FDA Structured Product Labels), the European Medicines Agency centrally-authorised medicines database, the Plogsted curated gluten-free drug list, and the 2024 Mangione et al. pediatric pharmacy NDC analysis. Inactive ingredients are scanned against a 146-entry red-flag dictionary covering wheat, barley, rye, malt, source-ambiguous starches, and FDA gluten-free attestation phrases. Mostly yes — but worth a quick call to the manufacturer for some generics. Of 10 product labels we checked, 8 are clean, 0 are confirmed gluten-free by the maker, and 2 contain an inactive ingredient (typically a source-ambiguous starch) whose botanical origin isn't fully disclosed. None contained confirmed gluten.

Can different manufacturers' generic versions of trazodone have different gluten status?

Yes. Generics in the United States must use the same active ingredient as the brand, but they are not required to use the same inactive ingredients. Two generics of trazodone from different manufacturers can use entirely different starch sources, binders, and fillers. A pharmacy may also switch which manufacturer it dispenses between fills without notifying you. Each manufacturer-specific entry below corresponds to a separately-filed product label.

Last verified May 17, 2026 · 10 product labels screened

Is trazodone gluten-free?

Looks mostly clean — worth verifying with the maker. Mostly yes — but worth a quick call to the manufacturer for some generics. Of 10 product labels we checked, 8 are clean, 0 are confirmed gluten-free by the maker, and 2 contain an inactive ingredient (typically a source-ambiguous starch) whose botanical origin isn't fully disclosed. None contained confirmed gluten.

Drug context

About trazodone

Trazodone is a serotonin modulator used for depression and insomnia, sold under brand names including Desyrel.

Why this matters

Different manufacturers, different ingredients

Generics of trazodone use the same active ingredient, but they aren't required to use the same inactive ingredients. Your pharmacy may switch which manufacturer they dispense between fills, sometimes without telling you. The list below shows each manufacturer's product label as a separate entry, because that's the granularity that actually matters when you're celiac.

The labels

The 10 we checked

01

Golden State Medical Supply, Inc. worth a call to confirm

US label (DailyMed) · TRAZODONE HYDROCHLORIDE TABLET [GOLDEN STATE MEDICAL SUPPLY, INC.] · label dated May 06, 2026

Worth a call to the maker: SODIUM STARCH GLYCOLATE TYPE A

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · MAGNESIUM STEARATE · SILICON DIOXIDE · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A · STARCH, CORN
View source label →
02

Granules Pharmaceuticals Inc. worth a call to confirm

US label (DailyMed) · TRAZODONE HYDROCHLORIDE TABLET [GRANULES PHARMACEUTICALS INC.] · label dated May 01, 2026

Worth a call to the maker: SODIUM STARCH GLYCOLATE TYPE A

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · MAGNESIUM STEARATE · SILICON DIOXIDE · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A · STARCH, CORN
View source label →
03

St. Mary's Medical Park Pharmacy nothing flagged on the label

US label (DailyMed) · TRAZODONE HYDROCHLORIDE TABLET [ST. MARY'S MEDICAL PARK PHARMACY] · label dated Apr 17, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · MAGNESIUM STEARATE · SILICON DIOXIDE · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A POTATO · STARCH, PREGELATINIZED CORN
View source label →
04

NCS HealthCare of KY, LLC dba Vangard Labs nothing flagged on the label

US label (DailyMed) · TRAZODONE HYDROCHLORIDE TABLET [NCS HEALTHCARE OF KY, LLC DBA VANGARD LABS] · label dated Mar 30, 2026

Inactive ingredients ANHYDROUS LACTOSE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO
View source label →
05

Apotex Corp nothing flagged on the label

US label (DailyMed) · TRAZODONE HYDROCHLORIDE TABLET [APOTEX CORP] · label dated Mar 25, 2026

Inactive ingredients MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A POTATO · STARCH, CORN
View source label →
06

Coupler LLC nothing flagged on the label

US label (DailyMed) · TRAZODONE HYDROCHLORIDE TABLET, FILM COATED [COUPLER LLC] · label dated Mar 09, 2026

Inactive ingredients ANHYDROUS LACTOSE · CARNAUBA WAX · CROSPOVIDONE · HYPROMELLOSE, UNSPECIFIED · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · POLYETHYLENE GLYCOL, UNSPECIFIED · POLYSORBATE 80 · SILICON DIOXIDE · TITANIUM DIOXIDE
View source label →
07

Torrent Pharmaceuticals Limited nothing flagged on the label

US label (DailyMed) · TRAZODONE HYDROCHLORIDE TABLET [TORRENT PHARMACEUTICALS LIMITED] · label dated Mar 05, 2026

Inactive ingredients CELLULOSE, MICROCRYSTALLINE · MAGNESIUM STEARATE · SILICON DIOXIDE · SODIUM LAURYL SULFATE · SODIUM STARCH GLYCOLATE TYPE A POTATO · STARCH, PREGELATINIZED CORN
View source label →
08

AX Pharmaceutical Corp nothing flagged on the label

US label (DailyMed) · TRAZODONE HCL POWDER [AX PHARMACEUTICAL CORP] · label dated Mar 05, 2026
View source label →
09

Northwind Health Company, LLC nothing flagged on the label

US label (DailyMed) · TRAZODONE HYDROCHLORIDE TABLET [NORTHWIND HEALTH COMPANY, LLC] · label dated Feb 13, 2026

Inactive ingredients ANHYDROUS LACTOSE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO
View source label →
10

Northwind Health Company, LLC nothing flagged on the label

US label (DailyMed) · TRAZODONE HYDROCHLORIDE TABLET [NORTHWIND HEALTH COMPANY, LLC] · label dated Feb 06, 2026

Inactive ingredients ANHYDROUS LACTOSE · MAGNESIUM STEARATE · MICROCRYSTALLINE CELLULOSE · SILICON DIOXIDE · SODIUM STARCH GLYCOLATE TYPE A POTATO
View source label →

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Background

What “gluten in a medication” actually means

Gluten enters drugs through their excipients — the inactive ingredients used to bind, coat, fill, or stabilize the dose. The main concern is wheat starch as a filler. Source-ambiguous starches (plain “starch”, pregelatinized starch, sodium starch glycolate, modified starch) get flagged for verification because their botanical origin isn't always disclosed on the label.

The 2024 Mangione et al. pediatric NDC analysis (689 NDCs across the top 100 pediatric medications) found 1.5% contained gluten outright; another 25.7% couldn't be confirmed either way. Liquid and oral-suspension formulations carry disproportionate risk because wheat starch is a common thickener. Full methodology →

Keep checking

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Important. This page is informational. Drug labels can change without notice; a manufacturer attestation is point-in-time, not a warranty. If you have celiac disease and your pharmacy switches manufacturers, re-screen the new label before taking the dispensed product. For a definitive answer, call the manufacturer's medical-information line with the NDC code from your prescription bottle.